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Multinucleate epidermal cells in non-neoplastic dermatoses

S Kimura, H Hatano

The British Journal of Dermatology

|November 1, 1978

Summary

Multinucleate epidermal cells (MEC), arising from keratinocytes, were found in various non-neoplastic skin conditions. Their formation mechanism may involve dyskeratosis, similar to Bowen

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Area of Science:

Dermatopathology
Cell Biology

Background:

Multinucleate epidermal cells (MEC), derived from keratinocytes, are observed in various non-neoplastic dermatoses.
These cells typically present with two or three nuclei and exhibit perinuclear eosinophilic material.
A correlation between MEC formation and dyskeratosis is noted in conditions like Hailey-Hailey disease.

Purpose of the Study:

To investigate the occurrence and potential mechanism of multinucleate epidermal cell formation in non-neoplastic dermatoses.
To explore the relationship between MEC formation and dyskeratosis in specific skin conditions.

Main Methods:

Histological examination of 197 cases of non-neoplastic dermatoses.
Analysis of cell morphology, including nuclear count and presence of eosinophilic material.
Correlation of MEC presence with specific dermatoses and dyskeratotic tendencies.

Main Results:

MEC were identified in 92 out of 197 cases (46.7%).
Commonly observed in lupus erythematosus, lichenoid eruptions, psoriasis vulgaris, and Hailey-Hailey disease.
Positive staining for tonofilaments in perinuclear bands suggests involvement of epidermal fibers.

Conclusions:

The formation of MEC in these dermatoses likely involves a mechanism similar to Bowen's disease, characterized by entangled dyskeratotic tonofilaments.
This process impedes normal cell division, leading to multinucleation.
MEC appear to be a histological manifestation of both malignant and benign dyskeratosis.

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