Related Experiment Video
Updated: Mar 29, 2026
08:01
Measurement of Insulin- and Contraction-Stimulated Glucose Uptake in Isolated and Incubated Mature Skeletal Muscle from Mice
Published on: May 16, 2021
6.8K
Local cerebral glucose utilization in hypothermic and hyperthermic rats
Journal of Neurochemistry
|July 1, 1982
Summary
Body temperature significantly impacts glucose utilization across most central nervous system (CNS) regions in rats. Temperature changes cause varied effects on glucose metabolism, highlighting the need for careful interpretation of brain imaging studies.
Area of Science:
- Neuroscience
- Physiology
- Metabolism
Background:
- Glucose utilization is a key indicator of brain activity.
- Body temperature fluctuations can affect physiological processes, including brain metabolism.
Purpose of the Study:
- To investigate the regional effects of hypothermia and hyperthermia on glucose utilization in the rat central nervous system (CNS).
- To determine if alterations in glucose metabolism are uniform across different brain regions under varying body temperatures.
Main Methods:
- Local glucose utilization was measured in 38 CNS regions of conscious rats.
- Rats were subjected to normothermic, hypothermic, and hyperthermic conditions.
- The 2-deoxyglucose autoradiographic method was employed.
Main Results:
- A significant relationship between glucose utilization and body temperature was found in 34 out of 38 CNS regions.
- Hypothermia most markedly reduced glucose use in thalamic nuclei, extrapyramidal/motor areas, and the septohippocampal formation.
- Hyperthermia increased glucose utilization in specific regions like the hypothalamus and hippocampus, while minimally affecting others like the neocortex and thalamus.
Conclusions:
- Body temperature exerts a significant, regionally heterogeneous influence on glucose utilization in the rat CNS.
- The findings underscore the importance of controlling for body temperature in 2-deoxyglucose studies to ensure accurate interpretation of brain metabolic activity.
