Pharmacokinetics of rosoxacin in human volunteers

Reversed-phase liquid chromatography was used to determine plasma rosoxacin concentrations in normal, healthy males, each of whom received one 300 mg capsule of rosoxacin. The plasma data for each subject were described by an open one-compartment body model with first-order absorption, and the pharmacokinetic parameters were determined. The mean (+/- SE) apparent first-order terminal elimination rate constant was 0.203 +/- 0.015 hr-1 (N = 16), the mean apparent volume of distribution was 0.644 +/- 0.050 liters/kg, and the mean apparent plasma clearance was 2.08 +/- 0.15 ml/min/kg.