Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rat bladder irrigation with PVP-I2

D P Miller, E D Everett, B H Hamory

    The Journal of Urology
    |June 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Metabolic Signaling and Spatial Interactions in the Oral Polymicrobial Community.

    Journal of dental research·2019
    Same author

    Avoidance learning and classical eyeblink conditioning as model systems to explore a learning diathesis model of PTSD.

    Neuroscience and biobehavioral reviews·2019
    Same author

    Transcriptome analysis of Porphyromonas gingivalis and Acinetobacter baumannii in polymicrobial communities.

    Molecular oral microbiology·2018
    Same author

    Plasminogen binding and degradation by Treponema denticola: Identification of the plasminogen binding interface on the FhbB protein.

    Molecular oral microbiology·2018
    Same author

    Structure-function aspects of the Porphyromonas gingivalis tyrosine kinase Ptk1.

    Molecular oral microbiology·2016
    Same author

    The Treponema denticola AtcR LytTR domain-containing response regulator interacts with three architecturally distinct promoter elements: implications for understanding the molecular signaling mechanisms that drive the progression of periodontal disease.

    Molecular oral microbiology·2014
    Same journal

    On the Memoryless Property in Markov Models for NMIBC Cost-Effectiveness Analysis.

    The Journal of urology·2026
    Same journal

    Multi-institutional Assessment of Performance Metrics for MRI-targeted Transperineal Prostate Biopsy.

    The Journal of urology·2026
    Same journal

    Urinary Supersaturation in a Randomized Trial among Individuals with Recurrent Nephrolithiasis comparing Empiric versus Selective Preventive Therapy: The URINE Trial.

    The Journal of urology·2026
    Same journal

    The FDA Should Allow More BCG Strains into the US Market: How Recent Landmark Trials Expose a Regulatory Paradox.

    The Journal of urology·2026
    Same journal

    Let's Shift the Focus from Death to Life after Fournier's Gangrene.

    The Journal of urology·2026
    Same journal

    Endourology and Nephrolithiasis.

    The Journal of urology·2026
    See all related articles

    Povidone-iodine 2% (PVP-I2) irrigation showed no increased bladder toxicity in rats compared to catheterization alone. This suggests PVP-I2 is a safe option for preventing Foley catheter-associated urinary tract infections.

    Area of Science:

    • Urology
    • Infectious Diseases
    • Toxicology

    Background:

    • Foley catheter-associated urinary tract infections (CAUTIs) remain a significant cause of hospital-acquired infections.
    • Povidone-iodine 2% (PVP-I2) exhibits bactericidal properties against CAUTI-causing organisms and is non-irritating to tissues.

    Purpose of the Study:

    • To evaluate the toxicity of PVP-I2 irrigation on catheterized rat bladders.
    • To measure systemic iodine absorption following PVP-I2 bladder irrigation.

    Main Methods:

    • Rats underwent surgical placement of bladder catheters.
    • Groups received either no irrigation, PBS irrigation, or dilute PVP-I2 irrigation every 8 hours.
    • Bladder tissues were histologically examined, and blood samples analyzed for protein-bound iodine (PBI), T3, and T4 levels at 1 and 2 weeks.

    Related Experiment Videos

    Main Results:

    • No significant differences in bladder ulceration, erythema, or inflammation were observed between groups.
    • Rats receiving PVP-I2 irrigation showed higher PBI levels compared to control groups (p < 0.05).
    • Thyroid hormone levels (T3, T4) remained unchanged across all groups.

    Conclusions:

    • PVP-I2 irrigation demonstrated no additional bladder toxicity compared to catheterization alone or PBS irrigation in rats.
    • The study supports the potential safety of using PVP-I2 for managing CAUTIs.