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07:58
Use of Image Cytometry for Quantification of Pathogenic Fungi in Association with Host Cells
Published on: June 19, 2013
Cephalic phycomycosis: a report of eight cases
The Laryngoscope
|July 1, 1982
Summary
Phycomycosis, a devastating fungal infection, often affects immunocompromised individuals. Early diagnosis and treatment, including amphotericin B, improve survival rates but mortality remains significant.
Area of Science:
- Mycology
- Infectious Diseases
- Clinical Medicine
Background:
- Phycomycosis is a severe fungal infection caused by nonseptate hyphae from genera like Rhizopus, Mucor, and Absidia.
- It frequently affects patients with underlying conditions such as diabetes mellitus, leukemia, and immunosuppression.
Observation:
- Cephalic phycomycosis presents in two forms: rhino-orbital cerebral (often fatal) and rhino-paranasal sinuses (typically benign).
- Historically, the cephalic form had a 50% mortality rate; modern therapy, including amphotericin B, has reduced this to approximately 30%.
Findings:
- Intracranial involvement in cephalic phycomycosis portends a poor prognosis, even with contemporary treatments.
- Computed Tomography (CT) scans are crucial for identifying orbital and intracranial extensions of the disease.
Implications:
- Despite therapeutic advancements, phycomycosis remains a critical condition requiring vigilant management.
- Further research into novel therapeutic strategies is warranted to improve outcomes for patients with severe phycomycosis, particularly those with intracranial involvement.
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