"Pink" diarrhoea: osmotic diarrhoea from a sorbitol-containing vitamin C supplement

Insights

Sorbitol in vitamin C supplements caused prolonged diarrhea in seven children. Doctors recommend dietary changes and sorbitol exclusion for unexplained watery diarrhea in kids.

Area of Science:

  • Pediatric Gastroenterology
  • Clinical Nutrition
  • Toxicology

Background:

  • Protracted diarrhea is a common pediatric concern requiring thorough investigation.
  • Identifying dietary triggers is crucial for managing chronic gastrointestinal issues in children.

Observation:

  • Seven pediatric patients presented with prolonged watery diarrhea.
  • Sorbitol, administered via vitamin C supplements, was identified as the causative agent in all cases.
  • Pink staining of napkins, linked to cochineal dye in supplements, was noted in five patients.

Findings:

  • Sorbitol is a sole cause of protracted diarrhea in susceptible children.
  • Vitamin C supplements containing sorbitol and cochineal dye can induce chronic diarrhea and distinctive napkin staining.
  • Dietary history is key in diagnosing sorbitol-induced diarrhea.

Implications:

  • Clinicians should consider sorbitol in vitamin C supplements when evaluating pediatric chronic diarrhea.
  • Excluding sorbitol from the diet is a recommended initial step before extensive diagnostic workups.
  • Awareness of hidden sorbitol sources in supplements can prevent unnecessary medical interventions.

Related Concept Videos

Glucose Transporters01:27

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Hyperosmolar Hyperglycemic State01:21

Hyperosmolar Hyperglycemic State

Hyperosmolar Hyperglycemic State, or HHS, is a serious and life-threatening complication of type 2 diabetes mellitus. It is characterized by three main features: severe hyperglycemia, profound dehydration, and elevated serum osmolality, all occurring without significant ketoacidosis.HHS typically develops in older adults or individuals with limited access to fluids. This may result from illness, cognitive impairment, or medications such as diuretics or corticosteroids. These factors reduce...
Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...