Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Visual system dysfunction following acute trimethyltin exposure in rats

R S Dyer, W E Howell, W F Wonderlin

    Neurobehavioral Toxicology and Teratology
    |March 1, 1982
    PubMed
    Summary

    Trimethyltin (TMT) exposure damages the visual system, affecting retinal processing and arousal. This study reveals TMT

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Prunus tomentosa as a Diagnostic Host for Detection of Plum Pox Virus and Other Prunus Viruses.

    Plant disease·2019
    Same author

    Isolation and Partial Characterization of a Filamentous Virus Associated with Peach Mosaic Disease.

    Plant disease·2019
    Same author

    Molecular Evidence of the Relationship Between a Virus Associated with Flat Apple Disease and Cherry rasp leaf virus as Determined by RT-PCR.

    Plant disease·2019
    Same author

    Characterization of Cherry leafroll virus in Sweet Cherry in Washington State.

    Plant disease·2019
    Same author

    Evaluation of i-STAT creatinine assay.

    Nephron·2001
    Same author

    Translocon pores in the endoplasmic reticulum are permeable to a neutral, polar molecule.

    The Journal of biological chemistry·2001

    Area of Science:

    • Neuroscience
    • Toxicology
    • Sensory Systems

    Background:

    • Trimethyltin (TMT) is known to cause damage in the limbic system.
    • Previous research has not reported TMT-induced damage to sensory systems.
    • The visual system's integrity following TMT exposure requires investigation.

    Purpose of the Study:

    • To investigate the effects of acute trimethyltin chloride (TMT) exposure on the integrity of the rat visual system.
    • To determine if TMT alters visual evoked responses.
    • To explore potential retinal processing and arousal alterations.

    Main Methods:

    • Rats were chronically implanted with electrodes for recording visual evoked potentials.
    • Photic stimulation was used to elicit responses from the visual cortex and optic tract.
    • Animals received acute exposure to varying doses of TMT (0, 4, 5, 6, or 7 mg/kg) or saline.

    Main Results:

    • TMT exposure induced significant alterations in visual evoked responses.
    • Increased early peak latencies and decreased amplitudes in the visual cortex and optic tract suggest retinal changes.
    • Decreased P3N3 amplitude and N3 latency in the visual cortex indicate increased arousal.

    Conclusions:

    • Trimethyltin (TMT) demonstrably alters the integrity of the visual sensory system.
    • TMT exposure affects both retinal processing and the overall arousal state.
    • These findings expand the known neurotoxic effects of TMT beyond the limbic system.

    Related Experiment Videos