Effects of triethyltin on schedule dependent and schedule induced behaviors under different schedules of...

The subacute effects of triethyltin (TET) on operant responding and adjunctive behavior were assessed using either a fixed ratio (FR-30) or fixed interval (FI-1 min) schedule of reinforcement. Response rate decreased for rats on the FR-30 schedule given 1.5 mg/kg whereas animals on the FI-1 min schedule showed decreases in presses and pellets obtained at 1.5 mg/kg and in water intake at 1.0 and 1.5 mg/kg. When the animals on the FI-1 min schedule were allowed to recover body weight, decreases in presses, pellets obtained, licking, and water intake occurred at 0.5, 1.0 and 1.5 mg/kg. Schedule induced and schedule dependent behaviors were affected by low doses of TET. Rats at recovered body weight were most sensitive and affected by the lowest TET doses.