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[Skeletal changes in non-Hodgkin lymphoma]

R Spanedda, P N Scutellari, G Marinelli

    Minerva Medica
    |June 16, 1982
    PubMed
    Summary

    Skeletal involvement in non-Hodgkin lymphoma (NHL) occurs in 10% of patients, primarily as osteolytic lesions. Early-stage disease shows no bone changes, with aggressive lymphomas being the only type with bone dissemination.

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    Area of Science:

    • Oncology
    • Radiology
    • Hematology

    Background:

    • Non-Hodgkin lymphoma (NHL) is a diverse group of lymphoid malignancies.
    • Skeletal involvement can occur in NHL, impacting diagnosis and prognosis.
    • Radiographic assessment is crucial for understanding disease extent.

    Purpose of the Study:

    • To investigate the incidence and patterns of skeletal involvement in non-Hodgkin lymphoma (NHL).
    • To analyze the radiographic findings of bone dissemination in NHL patients.
    • To evaluate the role of skeletal imaging in the management of NHL.

    Main Methods:

    • Retrospective analysis of 140 patients with non-Hodgkin lymphoma (NHL).
    • Review of radiographic skeletal investigations for metastatic involvement.
    • Classification of bone lesions including osteolytic, osteosclerotic, and mixed patterns.

    Main Results:

    • Skeletal involvement was observed in 10% (14/140) of NHL patients.
    • Bone dissemination was exclusively found in aggressive lymphoma subtypes.
    • The most common finding was osteolytic lesions (35.6%), particularly the 'permeative' pattern.
    • Osteosclerotic and mixed lesions were less frequent (7.2% each).
    • No periosteal reactions were noted.
    • Bone changes were absent at the initial disease presentation.

    Conclusions:

    • Skeletal involvement in NHL is relatively uncommon but significant, primarily manifesting as osteolytic lesions.
    • Radiographic skeletal surveys are valuable for diagnosing, staging, and monitoring NHL.
    • Early-stage disease and non-aggressive lymphomas typically do not present with bone involvement.

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