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HLA and longevity

J Proust, R Moulias, F Fumeron

    Tissue Antigens
    |March 1, 1982
    PubMed
    Summary
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    Certain human leukocyte antigen (HLA) haplotypes may offer a survival advantage. This study found specific HLA antigen associations in elderly males and females, suggesting a link to longevity.

    Area of Science:

    • Immunogenetics
    • Longevity Research
    • Human Leukocyte Antigen (HLA) Complex

    Background:

    • The Human Leukocyte Antigen (HLA) complex plays a crucial role in immune response.
    • Investigating HLA antigen frequencies in centenarians can provide insights into genetic factors influencing exceptional longevity.

    Purpose of the Study:

    • To analyze HLA antigen distribution and heterozygosity in healthy nonagenarians.
    • To compare HLA profiles between elderly individuals and a younger control group.
    • To identify potential HLA associations with survival advantage.

    Main Methods:

    • Phenotyping of HLA-A, -B, -C, and -DR loci in 155 French Caucasian nonagenarians.
    • Comparison of antigen frequencies with a control group (aged 10-50 years).

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  • Statistical analysis to assess antigen distribution, heterozygosity, and haplotype associations, considering sex differences.

    • Main Results:

    • No significant overall differences in HLA antigen distribution or heterozygosity between nonagenarians and the control group.
    • Significant excess of HLA-Cw1 antigen in elderly females (p < 0.001).
    • Significant excess of HLA-Cw7 antigen in elderly males (p < 0.001), notably within the A1/Cw7/B8/DR3 haplotype, which was increased in male nonagenarians (p < 0.001).

    Conclusions:

    • Specific HLA haplotypes, particularly A1/Cw7/B8/DR3, may be associated with increased survival.
    • Sex-specific differences in HLA antigen frequencies suggest a potential role in longevity.
    • These findings support the hypothesis of HLA-associated survival advantages.