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Related Experiment Videos

Microfibril formation in chick notochordal cells

T Kayahara

    Tissue & Cell
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Electron microscopy revealed dense bodies containing microfibrils in chick notochord cells. These findings suggest notochord cells contribute to microfibril formation, impacting overall notochord development.

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    Area of Science:

    • Developmental Biology
    • Cell Biology
    • Electron Microscopy

    Background:

    • The notochord is a crucial transient structure in vertebrate embryonic development.
    • Understanding the cellular mechanisms of notochord formation is key to developmental biology.

    Purpose of the Study:

    • To investigate the ultrastructure of central chick notochord cells.
    • To identify the origin and composition of microfibrils within the notochord.

    Main Methods:

    • Transmission electron microscopy was used to examine chick notochord sections at Hamburger and Hamilton's stages 20-22.
    • Analysis focused on the morphology and location of intracellular and extracellular fibrous material.

    Main Results:

    • Electron-dense bodies containing microfibrils (120-600 A diameter) were observed in central notochord cells.

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  • These microfibrils exhibited periodic structures (approx. 320 A interval).
  • Intracellular microfibrils showed similarities to extracellular fibrous material in the notochord.

    • Conclusions:

    • Central and peripheral notochord cells are capable of synthesizing microfibrils.
    • These cells likely contribute significantly to the fibrillogenesis of the notochord.
    • The findings provide insights into the cellular basis of notochordal extracellular matrix formation.