Dissociation between renal gluconeogenesis and ammoniagenesis after acute liver intoxication

Renal glucose and ammonia production as well as phosphoenolpyruvate carboxykinase and phosphate-dependent glutaminase activities were measured for acute liver intoxication. Gluconeogenesis and phosphoenolpyruvate carboxykinase activity increased, whereas ammonia production and phosphate-dependent glutaminase showed no changes with respect to the controls. The dissociation between gluconeogenesis and ammoniagenesis may be explained by the differential effect on the enzymes in these conditions.