Structure-toxicity relationship of acrylates and methacrylates

The structure-toxicity relationships of acrylates and methacrylates were analysed in mice. In all test compounds, the acute oral toxicity (LD), the partition coefficient (P), and the second order rate constant (K) with reduced glutathione were measured experimentally. The toxicities of both acrylates and methacrylates were found to be dependent significantly upon log P or log K, especially upon the former. The correlation coefficient between log (1/LD50) and log P, was -0.9909 for acrylates and -0.795 for methacrylates, both being statistically significant. The correlation coefficient between log P and log K was -0.935 for acrylates and -0.744 for methacrylates.