Clearance and distribution of intratracheally instilled vanadium compounds in the rat

Intratracheally instilled 48V2O5 was rapidly cleared from the lung into blood, liver and bone. Approx. 40% of the recovered 48V was excreted, primarily in urine by day 3, while the skeleton accounted for 30% by day 7. The behavior of instilled 48VO2Cl was similar to that of 48V2O5. Uptake of gavaged 48V2O5 was 2.6% of administered dose. Skeleton, lung, kidney and liver are primary targets for intratracheally instilled 48V with uptake being much greater via the intratracheal route than by the oral route.