Structure-neurotoxicity relationships applied to organophosphorus pesticides

Phosphorofluoridates, phosphonofluoridates and phosphorodiamidofluoridates were used as model compound in studying quantitative structure-neurotoxicity relationships. The minimum dose (mg/kg i.m., hen) producing ataxia after 12 days was regressed against physiochemical parameters. It was shown by using the response surface optimization of the MASCA model, that the neurotoxicity depended on lipophilic and steric substituent properties.