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Related Experiment Videos

Volume changes in the rat renal cortex during urography

V Hegedüs, P Faarup, T Nørgaard

    The British Journal of Radiology
    |October 1, 1978
    PubMed
    Summary

    Kidney cortex volume rapidly changes during urography. Hypertonic contrast medium causes immediate increases and subsequent decreases in rat kidney volume within minutes.

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    Area of Science:

    • Nephrology
    • Renal Physiology
    • Radiology

    Background:

    • Urography involves intravenous injection of contrast media.
    • Understanding kidney structural changes during urography is crucial for interpreting imaging studies.
    • Previous studies have not fully detailed the dynamic volumetric changes in renal cortical compartments.

    Purpose of the Study:

    • To elucidate the structural basis of renal cortical volume variations during urography.
    • To quantify dynamic changes in different cortical compartments and tubular fractions.
    • To determine the temporal course of these volume alterations.

    Main Methods:

    • Rat kidneys were instantly frozen at -165°C at various time points during urography.
    • Histological techniques and planimetry were employed to analyze cortical compartments.
    • Volume shares of different cortical compartments and tubular fractions (cellular and luminal) were measured.

    Main Results:

    • The renal cortex exhibited an immediate volume increase post-contrast injection.
    • A subsequent decrease in cortical volume was observed between 30 and 60 seconds.
    • Complex volume variations were noted in cortical compartments and tubular fractions.
    • Major volume changes concluded approximately three minutes after injection.

    Conclusions:

    • Renal cortical volume undergoes dynamic and complex changes during the initial minutes of urography.
    • These volumetric alterations involve both cellular and luminal fractions of tubular compartments.
    • The findings provide a structural basis for understanding urographic imaging of the kidney.

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