[Morphometric ultrastructural analysis in laryngeal cancer]

A comparative electron microscopy study of the ultrastructures of cancer cell and normal stratified squamous epithelium of human larynx was carried out in bioptical and resected material to identify characteristics of cataplasia development in laryngeal squamous-cell carcinoma. A morphometrical analysis showed the two following indices of quantitative evaluation of cellular ultrastructures of laryngeal squamous-cell carcinoma to provide most information on the degree of cataplasia development: the development of an independent polyribosomal apparatus which points to the level of "intracelluar" protein synthesis and the level of total protein synthesis in cell cytoplasm. Cataplasia progression is accompanied by the advancement of the structural and functional organisation of both polyribosomal apparatus and ergastoplasm.