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[Course of influenza in cyclophosphane suppression of cellular and humeral immunity]
Under conditions of immunosuppression of B- and T-cell functions with cyclophosphane, experimental influenza in mice infected with A/Aichi/2/68 (H3N2) runs early in the infection a much milder course than in mice given no such treatment. The mortality among immunosuppressed mice was 5 times as low as in the controls; the virus could be isolated from the lung tissue earlier and in higher titres; cyclophosphane inhibited the synthesis of antibodies and nonspecific thermolabile and thermostable tissue and serum inhibitors. Hepatization of the lungs in immunosuppressed animals was considerably less marked. The effect of cyclophosphane appeared to depend on its antiinflammatory properties.
Under conditions of immunosuppression of B- and T-cell functions with cyclophosphane, experimental influenza in mice infected with A/Aichi/2/68 (H3N2) runs early in the infection a much milder course than in mice given no such treatment. The mortality among immunosuppressed mice was 5 times as low as in the controls; the virus could be isolated from the lung tissue earlier and in higher titres; cyclophosphane inhibited the synthesis of antibodies and nonspecific thermolabile and thermostable tissue and serum inhibitors. Hepatization of the lungs in immunosuppressed animals was considerably less marked. The effect of cyclophosphane appeared to depend on its antiinflammatory properties.