[Intravenous "pulsed" methylprednisolone treatment of severe collagenic and rapidly progressing glomerulonephritis]

The results are reported from the "pulse" methylprednisolone treatment of seven patients with severe collagenic and rapidly progressing glomerulonephritis. Good effect was obtained in six patients, manifested in increased and maintained relatively high diuresis, decreased proteinuria and erythocyturia, slowed down ESR, lower values of plasma creatinine, increased creatinine, normalization of the majority of immunologic deviations. The patients with good effect were in a good condition till the end of the follow up, with no complaints, afebrile, without edemas and no manifestations of hypercorticism. The "pulse" intravenous methylprednisolone treatment is concluded to be an effective therapeutic method in rapidlyprogressing, abruptly deteriorated collagenic glomerulonephritis, as well as those with no effect after a combined anticoagulant, immunosuppressive and oral corticosteroid treatment.