Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epiretinal membrane formation after vitrectomy

W H Stern, S K Fisher, D H Anderson

    American Journal of Ophthalmology
    |June 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Occurrence of nodulation in the Leguminosae.

    The New phytologist·2021
    Same author

    A workflow for 3D-CLEM investigating liver tissue.

    Journal of microscopy·2020
    Same author

    The majestic canopy-emergent genus <i>Dinizia</i> (Leguminosae: Caesalpinioideae), including a new species endemic to the Brazilian state of Espírito Santo.

    Kew bulletin·2020
    Same author

    Kinins.

    Journal of the Royal College of Physicians of London·2019
    Same author

    Developing 3D SEM in a broad biological context.

    Journal of microscopy·2015
    Same author

    A novel RIPK4-IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes.

    Cell death and differentiation·2014
    Same journal

    Performance of the ISOLD Score (Interleukin Score for IntraOcular Lymphoma Diagnosis) in the Diagnosis of Vitreoretinal Lymphoma in Clinical Practice.

    American journal of ophthalmology·2026
    Same journal

    Reply to Comment on Visual Field Progression in Glaucoma Patients with Delayed Follow-Up.

    American journal of ophthalmology·2026
    Same journal

    Comment on: "Safety and efficiency reducing retinopathy of prematurity guideline sensitivity: an external validation using a large US-based dataset".

    American journal of ophthalmology·2026
    Same journal

    Reply to Comment on "Clinicopathological and Imaging Distinction Between Ocular Adnexal MALT Lymphoma and IgG4-Related Ophthalmic Disease".

    American journal of ophthalmology·2026
    Same journal

    Comment on: Visual Field Progression in Glaucoma Patients With Delayed Follow-Up.

    American journal of ophthalmology·2026
    Same journal

    Corneal sensitivity changes and nerve plexus abnormalities in noninfectious anterior uveitis.

    American journal of ophthalmology·2026
    See all related articles

    This study developed a rabbit eye model for epiretinal membrane formation after vitrectomy. This model helps research treatments to inhibit cellular proliferation and contraction in post-vitrectomy eyes.

    Area of Science:

    • Ophthalmology
    • Regenerative Medicine
    • Cell Biology

    Background:

    • Epiretinal membranes (ERMs) can cause vision loss after vitrectomy.
    • Current treatments for ERMs are limited, necessitating new research models.

    Purpose of the Study:

    • To establish an experimental model of epiretinal membrane formation in rabbit eyes.
    • To provide a platform for evaluating pharmacologic and surgical interventions against ERM development post-vitrectomy.

    Main Methods:

    • Rabbit eyes underwent lensectomy, vitrectomy, and fluid-gas exchange.
    • Tissue-cultured retinal pigment epithelial cells were injected onto the retinal surface.
    • Cellular proliferation and membrane formation were assessed using histology and tritiated-thymidine labeling.

    Related Experiment Videos

    Main Results:

    • A funnel-shaped detachment of medullary rays occurred in 100% of injected eyes within one week.
    • Epiretinal membranes formed within six hours, causing retinal wrinkling by 24-48 hours.
    • Tritiated-thymidine labeling confirmed significant epiretinal cell proliferation post-injection.

    Conclusions:

    • The rabbit eye model successfully replicates epiretinal membrane formation after vitrectomy.
    • This model is suitable for studying therapeutic strategies to inhibit ERM proliferation and contraction.
    • Further research can utilize this model to develop novel treatments for vision-threatening ERMs.