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Increased left atrial pressure does not alter renal function in the conscious primate
The American Journal of Physiology
|July 1, 1982
Summary
The atriorenal reflex, crucial for regulating body fluid balance, appears minimally involved in nonhuman primates. Unlike dogs, these primates showed no significant renal or cardiovascular changes when atrial pressure was increased.
Area of Science:
- Physiology
- Renal Physiology
- Cardiovascular Physiology
Background:
- The atriorenal reflex, mediated by atrial stretch receptors, plays a role in fluid homeostasis.
- Understanding this reflex in nonhuman primates is essential for comparative physiology.
Purpose of the Study:
- To investigate the functional significance of the atriorenal reflex in Macaca fascicularis.
- To determine the involvement of left atrial stretch receptors in volume regulation in nonhuman primates.
Main Methods:
- Chronic instrumentation of six Macaca fascicularis with left atrial snares and catheters.
- Measurement of hemodynamic and renal responses to increased left atrial pressure and blood volume expansion.
- Comparison of responses with those observed in conscious dogs.
Main Results:
- Increased left atrial pressure (from 6.5 +/- 3.3 to 16.2 +/- 3.4 mmHg) did not induce significant changes in renal or cardiovascular function in nonhuman primates.
- Nonhuman primates exhibited normal responses to a 15% blood volume expansion.
- Conscious dogs showed diuresis in response to elevated atrial pressure.
Conclusions:
- Left atrial stretch receptors are not critically involved in volume homeostasis in nonhuman primates.
- The atriorenal reflex's role in fluid balance differs between nonhuman primates and dogs.