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Related Experiment Videos

Decrease of basal plasma histamine levels by application of atropine in man

K Kubo, M Oka, R Frey

    Der Anaesthesist
    |April 1, 1982
    PubMed
    Summary
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    Atropine sulfate significantly reduces plasma histamine levels in oral surgery patients. This study demonstrates atropine

    Area of Science:

    • Pharmacology
    • Anesthesiology
    • Clinical Chemistry

    Background:

    • Histamine release can be a concern during surgical procedures.
    • Atropine sulfate is commonly used for premedication in surgery.

    Purpose of the Study:

    • To investigate the effect of atropine sulfate on plasma histamine levels.
    • To determine if atropine sulfate can suppress histamine release during oral surgery.

    Main Methods:

    • A comparative study involving 28 oral surgery patients.
    • Plasma histamine levels were measured using high-speed liquid chromatography.
    • Patients were divided into an atropine sulfate premedication group (n=11) and a non-atropine group (n=17).

    Main Results:

    Related Experiment Videos

  • The atropine sulfate group exhibited lower mean plasma histamine concentrations (0.32 ± 0.17 ng/mL) compared to the non-atropine group (0.68 ± 0.20 ng/mL).
  • Statistical significance was observed in the histamine levels between the two groups.

    • Conclusions:

    • Atropine sulfate demonstrates a histamine-suppressing effect in the context of oral surgery.
    • These findings suggest a potential benefit of atropine sulfate in managing histamine-related responses during surgical interventions.