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In Vivo Imaging and Tracking of Technetium-99m Labeled Bone Marrow Mesenchymal Stem Cells in Equine Tendinopathy

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Scintigraphic thyroid abnormalities after radiation. A controlled study with 99mTc pertechnetate scanning

C Gonzalez-Villalpando, L A Frohman, C Bekerman

Annals of Internal Medicine

|July 1, 1982

Summary

This summary is machine-generated.

Thyroid nodules, including nonpalpable ones, are linked to prior radiation therapy. Screening scintigraphy is recommended for high-risk individuals, even with normal palpation results.

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Area of Science:

Nuclear Medicine
Endocrinology
Oncology

Background:

Childhood radiation therapy for benign head and neck conditions is a known risk factor for thyroid abnormalities.
Previous studies have indicated a correlation between radiation exposure and thyroid nodule development.

Purpose of the Study:

To investigate the association between past therapeutic irradiation to the head or neck and the incidence of thyroid nodules.
To determine if scintigraphy can detect subclinical thyroid abnormalities in irradiated individuals.

Main Methods:

99mTc-pertechnetate thyroid scintigraphy was performed on 99 control subjects and 198 patients with a history of head/neck radiation.
Comparison of scintigraphic findings between irradiated patients and controls, with and without palpable nodules.

Main Results:

Significantly higher rates of abnormal thyroid scintigrams were observed in the irradiated group (55/198) compared to controls (1/99).
Abnormalities persisted even when palpable nodules were excluded (16/150 irradiated vs. 1/97 controls).

Conclusions:

Thyroid nodules, including nonpalpable ones detected by scintigraphy, are associated with previous radiation therapy.
Screening scintigraphy is supported for high-risk individuals (e.g., >700 R childhood exposure) with normal palpation findings.