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Timolol and acetazolamide. A study of concurrent administration
Archives of Ophthalmology (Chicago, Ill. : 1960)
|June 1, 1982
Summary
Combining topical timolol maleate and oral acetazolamide effectively lowers intraocular pressure. This combination therapy for glaucoma demonstrates significant additive ocular hypotensive effects.
Area of Science:
- Ophthalmology
- Clinical Pharmacology
Background:
- Glaucoma management often requires combination therapy to achieve target intraocular pressure.
- Topical timolol maleate and oral acetazolamide are established treatments for lowering intraocular pressure.
Purpose of the Study:
- To evaluate the additive ocular hypotensive effects of concurrent topical timolol maleate and oral acetazolamide administration.
- To determine the clinical utility of combining these two medications for intraocular pressure reduction.
Main Methods:
- A five-week clinical trial involving concurrent administration of the two drugs.
- Measurement of mean reduction in outflow pressure from baseline with each drug individually and in combination.
Main Results:
- Topical timolol maleate (0.5% every 12 hours) reduced outflow pressure by 36.0%.
- Oral acetazolamide (500 mg every 12 hours) reduced outflow pressure by 48.6%.
- Combined therapy showed additive effects, reducing outflow pressure significantly with only a slight decrease from predicted full additivity.
Conclusions:
- Concurrent administration of topical timolol maleate and oral acetazolamide is clinically useful for lowering intraocular pressure.
- The combination therapy provides significant additive ocular hypotensive effects, supporting its use in glaucoma management.