[Inhibition of fructose-induced hyperuricacidemia by pretreatment with phosphates]

To test the hypothesis that intravenous injections of fructose rapidly decreases liver ATP and Pi and results in the rapid degradation of adenine nucleotides and hyperuricemia, fructose was administered intravenously to a group of normal and gouty subjects; 4 gouty patients were treated with a phosphate solution prior fructose loading. The results obtained show that fructose administration plus phosphate solution prevents Pi depletion and inhibits fructose-induced hyperuricemia.