Prophylaxis against systemic infection after transrectal biopsy for suspected prostatic carcinoma
British Medical Journal
|November 4, 1978
Summary
Transrectal prostatic biopsy frequently causes bacteremia (bacteria in the blood). Routine blood cultures are recommended for all patients, even with antibiotic prophylaxis, to monitor for bloodstream infections.
Area of Science:
- Urology
- Infectious Disease
Background:
- Transrectal prostatic biopsy is a common urological procedure.
- Bacteremia following prostate biopsy can lead to serious complications.
Purpose of the Study:
- To investigate the incidence of bacteremia after transrectal prostatic biopsy.
- To evaluate the effectiveness of antibiotic prophylaxis in preventing post-biopsy infections.
- To determine the necessity of routine blood cultures.
Main Methods:
- Blood cultures were performed on patients five minutes after transrectal prostatic biopsy.
- Antibiotic prophylaxis (ampicillin and metronidazole for 48 hours) was administered routinely.
- Follow-up blood cultures were taken four days post-procedure.
Main Results:
- 16 out of 21 patients (76%) showed bacteremia five minutes post-biopsy.
- Antibiotic prophylaxis successfully prevented progression to septicemia.
- All blood cultures were negative by day four in patients receiving antibiotics.
Conclusions:
- Bacteremia is a common complication of transrectal prostatic biopsy.
- Antibiotic prophylaxis appears effective in preventing septicemia.
- Routine blood cultures are recommended for all patients undergoing this procedure, regardless of antibiotic use.
