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Labetalol in general practice: a review

J A Kane

    British Journal of Clinical Pharmacology
    |June 1, 1982
    PubMed
    Summary

    Labetalol effectively treats hypertension in many patients, with significant response rates in both severe and mild cases. Side effects were generally mild and transient, with no significant drug interactions observed.

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    Area of Science:

    • Pharmacology
    • Cardiovascular Medicine
    • General Practice

    Background:

    • Hypertension remains a significant global health concern.
    • Effective and safe antihypertensive medications are crucial for patient management.

    Purpose of the Study:

    • To review the efficacy and safety of labetalol in treating hypertensive patients in general practice.
    • To assess the response rates and side effect profile of labetalol across different severity levels of hypertension.

    Main Methods:

    • A review of published literature and unpublished data on labetalol treatment.
    • Analysis of data from 8573 hypertensive patients treated for 1 month to 5 years.
    • Evaluation of response rates based on diastolic blood pressure and side effect withdrawal rates.

    Main Results:

    • Satisfactory responses were observed in 60-80% of severe hypertensives and up to 88% of mild to moderate hypertensives.
    • Labetalol's antihypertensive effect was consistent regardless of administration frequency (twice or thrice daily).
    • Withdrawal rates due to side effects ranged from 6% to 13%, with common side effects including tiredness and dizziness, often transient.

    Conclusions:

    • Labetalol demonstrates significant efficacy in managing both severe and mild to moderate hypertension in a general practice setting.
    • The drug is generally well-tolerated, with transient side effects and no observed adverse hematological or biochemical changes.
    • Labetalol offers a flexible treatment option due to its consistent efficacy irrespective of dosing frequency.

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