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[Changes in the internal organs after hemodilution under hyperbaric oxygenation]

S N Efuni, L L Shimkevich, V G Tepliakov

    Biulleten' Eksperimental'Noi Biologii I Meditsiny
    |March 1, 1982
    PubMed
    Summary

    Experiments on dogs show that plasma substitutes for blood replacement are rapidly reversible and adaptive. Optimizing plasma substitute composition can stabilize the histohematic barrier, reducing organ strain during hyperbaric oxygenation.

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    Area of Science:

    • Physiology
    • Biochemistry
    • Experimental Medicine

    Context:

    • Blood replacement therapy and hemodilution are critical in various medical scenarios.
    • Understanding the impact of plasma substitutes on organ morphology and microcirculation is essential.
    • Hyperbaric oxygenation (HBO) presents unique physiological challenges and therapeutic opportunities.

    Purpose:

    • To investigate the morphological and functional adaptations of organs following blood replacement with plasma substitutes under hyperbaric conditions.
    • To elucidate the role of microcirculatory disorders in cellular changes induced by hemodilution.
    • To explore methods for stabilizing the histohematic barrier and optimizing plasma substitute composition.

    Summary:

    • Experimental canine models demonstrated that hemodilution with plasma substitutes (0.5-2.5 g/100 ml Hb) under hyperbaric oxygenation (3 at. abs.) resulted in adaptive and rapidly reversible morphological changes in cerebral hemispheres, heart, liver, kidneys, and lungs.

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  • Microcirculatory disturbances were identified as the primary driver of cellular alterations.
  • Blood analysis revealed a correlation between hemodilution extent, microvascular permeability, and energy metabolism shifts.

    • Impact:

    • Findings suggest that tailored plasma substitute formulations can mitigate functional stress on organ systems by stabilizing the histohematic barrier.
    • The study supports the application of hemodilution techniques combined with hyperbaric oxygenation as a viable alternative to donor blood transfusion in surgery and other medical fields.
    • This research provides a basis for developing safer and more effective blood substitutes and transfusion strategies.