Behavioral effects of systemic injection of ibotenic acid manifested without neuromorphological correlates

Behavioral and neuromorphological effects of intraperitoneally injected ibotenic acid (IBO) were investigated in rats. These injections led to a number of marked behavioral disturbances which ultimately resulted in the death of 6 of the 13 IBO-treated rats. Despite marked changes in behavior, no morphological changes could be detected in the brain tissue of the surviving rats.