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Updated: Oct 9, 2026

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
Published on: March 28, 2017
Conditions for the generation of high serum levels of C3DP
High titers of C3DP, a DNA-binding derivative of complement C3, have been reported to occur in the sera of individuals with active malignant disease. The mechanism of generation of C3DP remained obscure. We report here that C3DP is not generated in vitro under the conditions required for its isolation and subsequent assay. However, under certain storage conditions, all sera (normal and malignant) produce C3DP. This severely limits the usefulness of the assay for diagnostic and prognostic purposes.
High titers of C3DP, a DNA-binding derivative of complement C3, have been reported to occur in the sera of individuals with active malignant disease. The mechanism of generation of C3DP remained obscure. We report here that C3DP is not generated in vitro under the conditions required for its isolation and subsequent assay. However, under certain storage conditions, all sera (normal and malignant) produce C3DP. This severely limits the usefulness of the assay for diagnostic and prognostic purposes.

