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Pharmacokinetics of digoxin in C.A.P.D
Clinical and Experimental Dialysis and Apheresis
|January 1, 1982
Summary
Digoxin elimination via peritoneal dialysis (C.A.P.D.) is minimal. Patients undergoing C.A.P.D. do not require digoxin dose adjustments, as urinary excretion remains the primary elimination route.
Area of Science:
- Nephrology
- Pharmacology
- Internal Medicine
Background:
- Continuous Ambulatory Peritoneal Dialysis (C.A.P.D.) is a common treatment for end-stage renal disease.
- Digoxin is a cardiac glycoside commonly prescribed for heart failure and arrhythmias.
Purpose of the Study:
- To investigate the extent of digoxin elimination through peritoneal dialysis.
- To determine the impact of C.A.P.D. on digoxin pharmacokinetics.
Main Methods:
- Five patients undergoing C.A.P.D. were studied.
- Plasma digoxin levels and elimination via peritoneal dialysis and urinary excretion were measured over 3-4 days.
Main Results:
- Plasma digoxin half-life ranged from 54 to 141 hours.
- Peritoneal elimination of digoxin was low, ranging from 7 to 24 micrograms over 3-4 days.
- Urinary elimination ranged from 11 to 57 micrograms during the same period.
Conclusions:
- Peritoneal elimination of digoxin is insignificant during C.A.P.D.
- Digoxin dosage adjustments are not necessary for patients initiating C.A.P.D.