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Intraventricular hemorrhage in full-term neonates
Developmental Medicine and Child Neurology
|June 1, 1982
Summary
Intraventricular hemorrhage in term neonates often originates in the choroid plexus or germinal matrix. Neuropathological findings reveal associated brain and lung hemorrhages, with clinical signs not reliably differentiating affected infants.
Area of Science:
- Neonatal Pathology
- Neuropathology
Background:
- Intraventricular hemorrhage (IVH) is a critical condition in neonates.
- Understanding the neuropathological features of IVH in term infants is essential for diagnosis and management.
Purpose of the Study:
- To describe the neuropathological and general pathological characteristics of intraventricular hemorrhage in neonates born at term.
- To identify associated findings and neurological manifestations in affected infants.
Main Methods:
- Retrospective analysis of neuropathological and general pathological findings.
- Study included 32 neonates born at term with intraventricular hemorrhage.
Main Results:
- The most common site of bleeding was the choroid plexus, with a minority in the subependymal germinal matrix.
- Associated findings included meningeal venous congestion, periventricular white-matter necrosis, subarachnoid hemorrhage, pulmonary hemorrhages, hyaline membranes, and congenital heart defects.
- Affected infants often had low Apgar scores, short survival, and neurological signs like hypotonia, hyporeflexia, decreased activity, and seizures.
Conclusions:
- Intraventricular hemorrhage in term neonates presents with diverse neuropathological and systemic findings.
- Clinical signs are insufficient for reliable differentiation of distressed neonates with IVH.
- Consider IVH in term and premature neonates with perinatal asphyxia or neurological deterioration.