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Related Experiment Videos

Reversible neurosyphilis presenting as chronic mania

B F Hoffman

    The Journal of Clinical Psychiatry
    |August 1, 1982
    PubMed
    Summary

    Paranoid psychosis and schizophrenia symptoms were initially treated with neuroleptics. Diagnosis of general paresis was confirmed, leading to treatment cessation and symptom resolution.

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    Area of Science:

    • Neurology
    • Psychiatry
    • Infectious Diseases

    Background:

    • Initial diagnosis of paranoid psychosis and chronic schizophrenia.
    • Treatment with chlorpromazine initiated in an outpatient setting.

    Observation:

    • Patient presented with confusion, disorganization, and manic symptoms two years post-initial diagnosis.
    • Physical and serologic examinations of blood and cerebrospinal fluid (CSF) were conducted.

    Findings:

    • Confirmation of general paresis (neurosyphilis) as the underlying diagnosis.
    • Cessation of neuroleptic medication was achieved following appropriate treatment.

    Implications:

    • Highlights the importance of considering treatable organic causes for psychiatric symptoms.
    • Demonstrates successful management of neurosyphilis presenting with psychosis and mania.
    • Underscores the potential for misdiagnosis of psychiatric conditions when organic etiologies are overlooked.

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