Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Increased norepinephrine content in diabetic rat heart

H Fushimi, T Inoue, H Namikawa

    Journal of Biochemistry
    |May 1, 1982
    PubMed
    Summary

    Diabetic rats showed significantly higher heart norepinephrine levels, indicating early cardiac catecholamine disturbances before microangiopathic changes occur. This research clarifies diabetic cardiac neuropathy mechanisms.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Predictors for onset of extended-spectrum beta-lactamase-producing Escherichia coli-induced bacteraemia: a systematic review and meta-analysis.

    The Journal of hospital infection·2023
    Same author

    Predictors of hypervirulent Klebsiella pneumoniae infections: a systematic review and meta-analysis.

    The Journal of hospital infection·2023
    Same author

    DHA requirement of larval Japanese flounder Paralichthys olivaceus in the rotifer feeding period.

    Communications in agricultural and applied biological sciences·2014
    Same author

    A new approach for the identification of a Chinese traditional medicine, "Chuanxiong" by 18S ribosomal RNA gene sequences.

    Phytomedicine : international journal of phytotherapy and phytopharmacology·2012
    Same author

    Thymic large-cell neuroendocrine carcinoma: a disease neglected in the ESMO guideline?

    Annals of oncology : official journal of the European Society for Medical Oncology·2011
    Same author

    [matK and its nucleotide sequencing of crude drug chuanxiong and phylogenetic relationship between their species from China and Japan].

    Yao xue xue bao = Acta pharmaceutica Sinica·2003

    Area of Science:

    • Biochemistry
    • Cardiology
    • Endocrinology

    Background:

    • Diabetes mellitus can lead to cardiac neuropathy.
    • The underlying mechanisms, particularly concerning catecholamine levels in the heart, require further elucidation.
    • Hypertension is a common comorbidity in diabetic patients.

    Purpose of the Study:

    • To investigate the role of catecholamines in the development of cardiac neuropathy in diabetes mellitus.
    • To determine heart catecholamine concentrations in diabetic rats.
    • To explore the relationship between hypertension and cardiac catecholamine levels in diabetic models.

    Main Methods:

    • Wistar male rats were induced into diabetes mellitus using streptozotocin injection.
    • Catecholamine concentrations in heart tissue were quantified using high-performance liquid chromatography.

    Related Experiment Videos

  • Control groups included age-matched normal rats and Goldblatt-hypertensive rats.

    • Main Results:

    • Diabetic rats exhibited significantly elevated heart norepinephrine concentrations (8,380 +/- 300 pmol/g).
    • Diabetic-Goldblatt-hypertensive rats also showed increased norepinephrine levels (6,980 +/- 390 pmol/g).
    • No significant histological changes were observed in the hearts or kidneys of any rat group.

    Conclusions:

    • Elevated heart norepinephrine suggests early disturbances in catecholamine secretion in diabetic hearts.
    • These changes occur prior to the development of typical microangiopathic complications.
    • The findings contribute to understanding the pathogenesis of diabetic cardiac neuropathy.