Electrophysiological response properties of spinoreticular neurons in the monkey

Extracellular recordings were made from 29 spinoreticular cells in the spinal cords of anesthetized monkeys. The cells were in either the cervical or the lumbar enlargement, and they were identified by antidromic activation from the medial part of the pontomedullary reticular formation. More spinoreticular neurons were sampled in the cervical than in the lumbar cord. Most of the cells were contralateral to the side from which antidromic activation was observed, but a higher proportion of the spinoreticular neurons in the cervical enlargement than in the lumbar enlargement was ipsilateral to the antidromic stimulus. Three cells in the lumbar cord were antidromically activated not only from the reticular formation but also from the contralateral thalamus, confirming that some spinoreticular projections are formed by collaterals from spinothalamic cells. Most of the spinoreticular neurons were in the ventral horn in laminae VII and VIII, although a few were in laminae IV-VI. Nearly half of the spinoreticular cells in the sample could not be activated by any form of peripheral stimulation tested. The other cells could be activated by stimulation of receptive fields that varied from small to large, that were sometimes bilateral regions of the skin or deep tissues. Although some spinoreticular cells could be classified as low threshold or wide dynamic range, the largest proportion were high threshold, requiring noxious stimulation for their activation. Descending volleys resulting from stimulation in the reticular formation could often be shown to inhibit or to excite spinoreticular neurons. It can be concluded that at least some spinoreticular neurons may play a role in nociception.