Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ascorbate concentration in tissues from normal and buphthalmic rabbits

R R Fox, K W Lam, R Lewen

    The Journal of Heredity
    |March 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effects of syphilis infection among HIV-1-positive individuals on suppressive antiretroviral therapy.

    AIDS research and therapy·2022
    Same author

    An uncommon complication of infective endocarditis.

    Hong Kong medical journal = Xianggang yi xue za zhi·2015
    Same author

    Changes in the Attitude and Practice Toward End-of-Life Care: Perspective of Chinese Physicians in Medical Department.

    The American journal of hospice & palliative care·2014
    Same author

    Voxel-based approach to generate entire human metacarpal bone with microscopic architecture for finite element analysis.

    Bio-medical materials and engineering·2014
    Same author

    Authors' reply.

    Hong Kong medical journal = Xianggang yi xue za zhi·2014
    Same author

    Uncommon cause of severe pneumonia: co-infection of influenza B and Streptococcus.

    Hong Kong medical journal = Xianggang yi xue za zhi·2013
    Same journal

    Chromosome-scale genome assembly of the rice stink bug (Hemiptera: Oebalus pugnax) illuminates genome structure and gene family evolution in Pentatomidae.

    The Journal of heredity·2026
    Same journal

    Rapid Derivation of Cloning-Competent Cells from Peripheral Blood Advances Conservation Biobanking.

    The Journal of heredity·2026
    Same journal

    Genomic vulnerability to climate change of a poorly dispersing and threatened fish, the southern pygmy perch (Nannoperca australis).

    The Journal of heredity·2026
    Same journal

    The complete genomes of two hybridizing field crickets, Gryllus pennsylvanicus and Gryllus firmus.

    The Journal of heredity·2026
    Same journal

    Chromosome-level genome assembly and annotation of the transverse lady beetle Coccinella transversoguttata.

    The Journal of heredity·2026
    Same journal

    A Chromosome-Level Assembly of the Pine Processionary Moth (Thaumetopoea pityocampa) genome.

    The Journal of heredity·2026
    See all related articles

    Hereditary buphthalmos in rabbits lowers ascorbate concentration in ocular tissues like the lens and cornea. This suggests a defect in ascorbate transport or oxidation within the eye contributes to the condition.

    Area of Science:

    • Ocular biochemistry
    • Animal models of glaucoma
    • Nutrient transport mechanisms

    Background:

    • Previous research indicates a correlation between the severity of hereditary buphthalmos and reduced ascorbate levels in rabbit aqueous humor.
    • Ascorbate (vitamin C) is crucial for ocular health, and its depletion may impact vision.

    Purpose of the Study:

    • To investigate ascorbate concentrations in various tissues of buphthalmic rabbits compared to controls.
    • To determine if hereditary buphthalmos involves a systemic or localized defect in ascorbate transport.
    • To identify potential mechanisms underlying ascorbate depletion in the aqueous humor.

    Main Methods:

    • Analysis of ascorbate concentration in ocular and non-ocular tissues from age-matched buphthalmic and control rabbits.

    Related Experiment Videos

  • Comparison of ascorbate levels between different ocular tissues (aqueous humor, lens, cornea, ciliary body-iris, retina).

    • Main Results:

    • Ascorbate concentration was significantly lowered only in the lens and cornea of buphthalmic rabbits.
    • Tissues receiving ascorbate directly from the blood, such as the ciliary body-iris and retina, maintained normal ascorbate levels.
    • Ascorbate levels in the aqueous humor were progressively lower, correlating with buphthalmos severity.

    Conclusions:

    • The observed ascorbate reduction in buphthalmic rabbit eyes is localized to tissues dependent on aqueous humor for supply (lens and cornea).
    • A potential defect in ascorbate oxidation within the ciliary body-iris, a proposed step for transport into the eye, may cause the lowered aqueous humor ascorbate.
    • These findings suggest a specific ocular transport or metabolic issue, rather than a systemic ascorbate deficiency, in hereditary buphthalmos.