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Biological effects of nonalkaloid-containing fractions of Erythroxylon coca
Abstract:
Water soluble nonalkaloid fractions of Erythroxylon coca were screened in mice for their effects on oxygen utilization and central nervous system (CNS) activity. The fractions were screened in dogs for cardiovascular, blood glucose, and respiratory changes. No CNS effects were demonstrated in mice; however, there was a reduction in the oxygen utilization rate. Intravenous administration of the extract to dogs produced hyperglycemia, a reduction in heart rate, and a decrease in blood pressure. No substantial change in the respiratory rate and tidal or minute volumes were observed.
Insights
Water soluble Erythroxylon coca fractions reduced oxygen utilization in mice and caused hyperglycemia, reduced heart rate, and lowered blood pressure in dogs. No central nervous system effects were observed in either species.
Area of Science:
- Pharmacology
- Physiology
Background:
- Erythroxylon coca is known for its stimulant properties.
- Understanding the physiological effects of its nonalkaloid components is crucial for pharmacological research.
Purpose of the Study:
- To investigate the physiological effects of water-soluble nonalkaloid fractions of Erythroxylon coca.
- To assess impacts on oxygen utilization, central nervous system (CNS) activity, cardiovascular function, blood glucose, and respiration.
Main Methods:
- Screening of Erythroxylon coca fractions in mice for oxygen utilization and CNS activity.
- Intravenous administration of fractions to dogs to monitor cardiovascular, blood glucose, and respiratory parameters.
Main Results:
- No CNS effects were observed in mice, but oxygen utilization decreased.
- In dogs, intravenous administration led to hyperglycemia, reduced heart rate, and decreased blood pressure.
- No significant alterations in respiratory rate or volumes were noted in dogs.
Conclusions:
- Water-soluble nonalkaloid fractions of Erythroxylon coca exhibit significant physiological effects.
- These fractions impact metabolic and cardiovascular functions without demonstrable CNS activity in the tested models.