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Metergoline as a lactation inhibitor

A Caballero, A Palomo, C E Molina

    The Journal of Reproductive Medicine
    |April 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

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    Metergoline effectively prevents and suppresses lactation in women, achieving high success rates with no observed secondary effects. This study highlights its efficacy compared to bromoergocriptine and control groups.

    Area of Science:

    • Pharmacology
    • Endocrinology
    • Reproductive Medicine

    Background:

    • Lactation can be an unwanted side effect in certain medical situations.
    • Effective pharmacological interventions are needed for lactation inhibition and suppression.
    • Prolactin is the primary hormone responsible for lactation.

    Purpose of the Study:

    • To evaluate the efficacy of metergoline in preventing lactation.
    • To assess metergoline's effectiveness in suppressing established lactation.
    • To compare metergoline's prolactin-lowering effects with bromoergocriptine and a control group.

    Main Methods:

    • Metergoline administered at 12-16 mg/day for 5-10 days to prevent lactation in 600 patients.
    • Metergoline administered to 100 patients to suppress established lactation.

    Related Experiment Videos

  • Prolactin levels monitored and compared with bromoergocriptine (5 mg/day) and breast-binding control groups over 21 days.

    • Main Results:

    • Excellent or good results in 95%-99% of cases for lactation prevention.
    • Excellent or good results in 100% of cases for established lactation suppression.
    • Metergoline demonstrated effective prolactin reduction, comparable to bromoergocriptine.

    Conclusions:

    • Metergoline is a highly effective agent for both the inhibition and suppression of lactation.
    • The drug exhibits favorable safety profile with no secondary effects reported.
    • Metergoline's dopaminergic and antiserotonin properties contribute to its efficacy in managing lactation.