Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reye's syndrome and medication use

T J Halpin, F J Holtzhauer, R J Campbell

    JAMA
    |August 13, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Black Hole Spectroscopy and Tests of General Relativity with GW250114.

    Physical review letters·2026
    Same author

    GW250114: Testing Hawking's Area Law and the Kerr Nature of Black Holes.

    Physical review letters·2025
    Same author

    Upskilling clinicians in compression therapy for leg ulcers - "Planet Compression Day" initiative.

    Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing·2025
    Same author

    Exploring infection risk factors and multi-drug-resistant organisms (MDROs) in burn intensive care units: a multi-centre case-control study.

    The Journal of hospital infection·2025
    Same author

    Publisher's Note: "Ion optical design of the magnetic proton recoil neutron spectrometer for the SPARC tokamak" [Rev. Sci. Instrum. 95, 103502 (2024)].

    The Review of scientific instruments·2024
    Same author

    Overview of the neutron diagnostic systems for the SPARC tokamak.

    The Review of scientific instruments·2024

    Aspirin use was significantly higher in children who developed Reye's syndrome (RS) compared to controls. This association remained even after accounting for other symptoms, suggesting a potential link between aspirin and RS.

    Area of Science:

    • Pediatric Medicine
    • Epidemiology
    • Pharmacology

    Background:

    • Reye's syndrome (RS) is a serious condition affecting children.
    • Understanding potential triggers for RS is crucial for prevention.

    Purpose of the Study:

    • To investigate the association between medication use and Reye's syndrome in children.
    • To identify specific drugs that may be linked to RS development.

    Main Methods:

    • A case-control study design was employed, comparing 97 Reye's syndrome cases with 156 matched controls.
    • Medication use during the pre-RS illness period was recorded and analyzed.
    • Statistical analysis, including a multiple logistic model, was used to control for confounding factors.

    Main Results:

    Related Experiment Videos

    • Aspirin use was significantly more prevalent in Reye's syndrome cases (97%) than in controls (71%).
    • Acetaminophen use was lower in cases (16%) compared to controls (33%).
    • While most cases did not exceed recommended aspirin dosages, their doses were higher than controls, and no dose-response relationship with RS encephalopathy stage was found.

    Conclusions:

    • The study indicates a significant association between aspirin use and Reye's syndrome in children.
    • Further research is warranted to elucidate the mechanisms behind this association and inform public health recommendations regarding aspirin use in children with viral illnesses.