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Related Experiment Videos

Complement changes during exercise-induced asthma

C M Gwynn, R A Thompson

    Clinical Allergy
    |September 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Asthmatic children experiencing post-exercise wheezing showed more significant changes in complement levels, particularly haemolytic complement, after exercise. This suggests a potential link between complement system lability and exercise-induced bronchospasm.

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    Area of Science:

    • Immunology
    • Pulmonology
    • Exercise Physiology

    Background:

    • Exercise-induced bronchospasm (EIB) is a common condition in asthmatic individuals.
    • The role of the complement system in EIB is not fully understood.
    • Previous research suggests potential inflammatory pathways involved in EIB.

    Purpose of the Study:

    • To investigate the changes in complement levels in asthmatic children with and without post-exercise wheezing compared to non-asthmatic controls.
    • To explore the relationship between complement system activity and the occurrence of exercise-induced wheezing.

    Main Methods:

    • Participants included asthmatic children with (n=6) and without (n=?) post-exercise wheezing, and non-asthmatic adults (n=1).
    • Subjects underwent treadmill exercise.

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  • Serum complement levels (haemolytic complement, C4, C3 breakdown products) were measured pre- and post-exercise.

    • Main Results:

    • Asthmatic children who wheezed post-exercise exhibited the most significant fall in FEV1 and a rise in haemolytic complement.
    • Four of six asthmatic children with post-exercise wheezing showed inconsistent changes in C4 titres.
    • No C3 breakdown products were detected post-exercise in any group.

    Conclusions:

    • The complement system appears more labile in asthmatic individuals susceptible to exercise-induced bronchospasm.
    • Complement activation may play a role in the pathophysiology of EIB, although the exact mechanisms require further investigation.
    • Further research is needed to elucidate the precise role of complement in exercise-induced bronchospasm.