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[Aminoglycoside for the infectious disease associated with acute leukemia. Gentamicin intravenous drip administration
Abstract:
In 29 patients of infection diseases associated with acute leukemia, 60 to 160 mg/day of gentamicin was injected intravenously drip infusion. The results showed that 69.0% of the cases were clinically effective (excellent+good+fair), and 31% ineffective. Abnormal GOT and GPT level was temporarily noted in 2 cases and audiovestibular dysfunction in 1 case, which improved after the discontinuation of the injection. Safety of the intravenous drip administration of gentamicin was discussed. The patients with acute leukemia might easily have opportunistic infection by Gram negative rods and it is more advantageous to administer intravenously drip infusion than intramuscularly because of hemorrhagic tendency.
Insights
Intravenous gentamicin effectively treated infections in acute leukemia patients, with a 69% clinical success rate. This administration method is safer than intramuscularly due to bleeding risks in leukemia patients.
Area of Science:
- Infectious Diseases
- Hematology
- Pharmacology
Background:
- Acute leukemia patients are susceptible to opportunistic Gram-negative bacterial infections.
- Hemorrhagic tendencies in acute leukemia complicate intramuscular drug administration.
Observation:
- Gentamicin was administered intravenously via drip infusion to 29 patients with acute leukemia and associated infections.
- Dosage ranged from 60 to 160 mg/day.
Findings:
- A 69.0% clinical effectiveness rate (excellent+good+fair) was observed.
- 31.0% of cases were ineffective.
- Transient abnormal liver function (GOT/GPT) in 2 patients and audiovestibular dysfunction in 1 patient were noted, resolving after discontinuation.
Implications:
- Intravenous drip infusion of gentamicin is a viable and potentially advantageous treatment for infections in acute leukemia patients.
- This route of administration mitigates risks associated with intramuscular injections in patients with bleeding disorders.
- Monitoring for potential side effects like liver function abnormalities and ototoxicity is recommended.