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Toxicological findings in amoxapine overdose
Journal of Analytical Toxicology
|March 1, 1982
Summary
This study measured amoxapine concentrations in overdose cases. Amoxapine levels were highest in brain and liver tissue, significantly exceeding blood levels, with no metabolites detected.
Area of Science:
- Pharmacology
- Clinical Toxicology
Background:
- Amoxapine is an antidepressant with antipsychotic properties.
- Determining tissue concentrations is crucial for understanding drug distribution and toxicity.
Observation:
- Tissue concentrations of amoxapine were analyzed in two overdose cases.
- Extraction, GLC, UV spectra, and TLC methods were employed for amoxapine analysis.
Findings:
- Amoxapine concentrations in brain tissue (52-53.2 µg/g) were comparable to liver tissue (50-77 µg/g).
- Brain and liver amoxapine levels were substantially higher than blood concentrations (1.5-6 µg/mL).
- Key metabolites, 8-hydroxyamoxapine and 7-hydroxyamoxapine, were undetectable via TLC and GLC.
Implications:
- These findings provide insights into amoxapine's tissue distribution during overdose.
- Understanding amoxapine pharmacokinetics in overdose is vital for clinical management.
- The absence of detected metabolites suggests limited metabolic activity or rapid clearance in these cases.