Meconium peritonitis, intraperitoneal calcifications and cystic fibrosis

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Updated: Oct 24, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

L I Finkel, T L Slovis

    Pediatric Radiology
    |January 1, 1982
    PubMed

    Insights

    Meconium peritonitis with cystic fibrosis may lack calcifications, while its absence suggests cystic fibrosis. However, absence of calcification is not definitive for diagnosing meconium peritonitis etiology.

    Area of Science:

    • Pediatric Surgery
    • Neonatal Medicine
    • Medical Imaging

    Background:

    • Meconium peritonitis is a serious neonatal condition.
    • Cystic fibrosis is a genetic disorder affecting multiple organs, including the intestines.
    • Intraperitoneal calcifications are a common sign of meconium peritonitis.

    Purpose of the Study:

    • To investigate the association between meconium peritonitis and cystic fibrosis.
    • To determine the diagnostic value of intraperitoneal calcifications in differentiating meconium peritonitis with and without cystic fibrosis.

    Main Methods:

    • Retrospective review of twelve meconium peritonitis cases.
    • Analysis of the presence or absence of abdominal calcifications in relation to cystic fibrosis diagnosis.

    Main Results:

    • Five of twelve patients had cystic fibrosis; three (60%) showed calcifications, two (40%) did not.
    • All seven patients without cystic fibrosis had abdominal calcifications (100%).
    • Absence of calcification was observed in 40% of cystic fibrosis cases.

    Conclusions:

    • Intraperitoneal calcifications do not rule out cystic fibrosis in neonates with meconium peritonitis.
    • Absence of calcification favors cystic fibrosis but is not definitive.
    • Further investigation is needed to establish definitive etiological clues for meconium peritonitis.

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