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A clinical program of platelet cryopreservation

C A Schiffer, J Aisner, J P Dutcher

    Progress in Clinical and Biological Research
    |January 1, 1982
    PubMed
    Summary

    Platelet cryopreservation offers a vital source of compatible platelets for alloimmunized patients, proving effective for up to three years. This simple, cost-effective technology ensures excellent patient acceptance and consistent transfusion outcomes.

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    Area of Science:

    • Hematology
    • Transfusion Medicine
    • Cryobiology

    Background:

    • Alloimmunized patients often lack compatible platelet sources.
    • Platelet transfusions are critical for managing bleeding risks in certain patient populations.

    Purpose of the Study:

    • To describe a developed program for platelet cryopreservation.
    • To evaluate the effectiveness and feasibility of long-term platelet storage.

    Main Methods:

    • Utilized 5% dimethylsulfoxide as a cryoprotective agent for platelet preservation.
    • Implemented a cryopreservation program over eight years, including autologous transfusions for leukemia patients.

    Main Results:

    • Frozen platelets provided a substantial portion of transfusion needs for alloimmunized patients.
    • Platelets remained effective for at least three years with no significant loss of efficacy.
    • Transfusions showed consistent post-transfusion increments (two-thirds of fresh platelets) and shortened bleeding times.
    • No significant side effects were observed, with excellent patient acceptance.

    Conclusions:

    • Platelet cryopreservation is a simple, cost-effective, and reproducible technology.
    • This method provides a reliable source of histocompatible platelets for alloimmunized individuals.
    • The technology is suitable for broader implementation in blood bank settings.

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