[On the different release kinetics of water-soluble and lipid-soluble forms of hydroxyquinoline in oleogel ointment...

Studies using the model according to Horsch and Kögel showed that the release kinetics of the suspended water-soluble (but not lipid-soluble) drugs hydroxyquinoline sulphate and hydroxy-quinoline sulphate--potassium sulphate from oleogels is of a zero order. Differences in drug dispersity do not affect the release rates. Oleogels containing the lipid-soluble hydroxyquinoline base yielded undersaturated solution ointments, the release kinetics of which can be stated by a semilogarithmic relationship. There exists a linear correlation between the release rates and the product of the lipid solubility of the drug and the reciprocal apparent distribution coefficient.