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[Bromocriptin in organic depression (author's transl)]

H Schubert, W W Fleischhacker, I Demel

    Pharmacopsychiatria
    |May 1, 1982
    PubMed
    Summary

    Bromocriptine treatment for depression linked to brain lesions showed limited long-term efficacy. While some patients improved initially, side effects like nausea and vomiting were common, with one experiencing a manic episode.

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    Psychological medicine·2016

    Area of Science:

    • Neuroscience
    • Psychiatry
    • Pharmacology

    Context:

    • Investigating treatments for depression secondary to organic brain lesions.
    • Exploring the role of dopamine in depressive disorders.

    Purpose:

    • To evaluate the therapeutic efficacy of bromocriptine in patients with endogenomorphic depression due to organic brain lesions.
    • To assess the safety and tolerability of bromocriptine in this patient population.

    Summary:

    • Ten patients with depression from brain lesions received 40 mg of bromocriptine daily.
    • Psychometric and clinical assessments revealed a negative correlation between performance and depressive symptoms.
    • Short-term amelioration was observed, but only two patients maintained satisfactory responses long-term. Common side effects included nausea and vomiting; one patient developed a reversible manic syndrome.

    Impact:

    • Suggests limited utility of bromocriptine for long-term management of depression in organic brain lesions.
    • Highlights the need for further research into dopamine-deficit hypotheses and alternative treatments.
    • Underscores the importance of monitoring for side effects, including psychiatric adverse events.

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