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Effect of hypoxia on the acute toxicity of acrylonitrile
Research Communications in Chemical Pathology and Pharmacology
|May 1, 1982
Abstract:
The modifying effects of hypoxia (7% 02) on acute lethality; and concentration of tissues non-protein sulfhydryls (NPSH) after acrylonitrile (ACN) exposure were studied. Hypoxia plus ACN exposure in male rats produced a substantial increase in mortality and a greater decrease in NPSH than ACN or hypoxia alone. NPSH in blood did not decrease significantly as a result of hypoxia, ACN or the combination.