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A comment on the reference series with regard to multiple exposure evaluations in a case-referent study
Scandinavian Journal of Work, Environment & Health
|January 1, 1982
Summary
Case-control studies require careful selection of control groups to ensure accurate exposure assessment. Using population registers for controls, rather than hospital-based ones, minimizes bias in etiologic research.
Area of Science:
- Epidemiology
- Biostatistics
Background:
- Case-control studies are valuable for investigating multiple exposures related to disease etiology.
- Validity of these studies depends critically on the selection of an appropriate reference (control) group.
Purpose of the Study:
- To highlight the importance of adequate reference series selection in case-control studies.
- To discuss potential biases arising from non-representative control groups.
Main Methods:
- The study discusses the implications of different sources for control group recruitment.
- It contrasts the use of hospital-based or health-related registers versus general population registers.
Main Results:
- Control groups drawn from sources related to health status (e.g., hospital registers) can introduce bias if controls have disorders related to the exposure.
- General population registers provide a more accurate reflection of exposure frequencies in the source population of cases.
Conclusions:
- The choice of reference series is crucial for the validity of case-control studies, particularly for exposures like medication use.
- General population registers are generally preferred for control selection to minimize bias.