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Angio-immunoblastic lymphadenopathy

P Jacobs, L B Kahn, H S King

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |August 7, 1982
    PubMed
    Summary
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    Two patients with constitutional symptoms and lymphoma achieved complete remission with treatment. Treatments included levamisole and epipodophyllotoxin VP16-213, showing potential for managing advanced disease.

    Area of Science:

    • Oncology
    • Immunology

    Background:

    • Lymphoma diagnosis often involves constitutional symptoms and lymph node biopsy.
    • Identifying specific histopathological features is crucial for accurate diagnosis and prognosis.

    Observation:

    • Two patients presented with constitutional symptoms, hepatosplenomegaly, and lymphadenopathy.
    • Lymph node biopsies revealed lymphocytic lymphoma alongside specific reactive changes like prominent vascularization and eosinophilic material.

    Findings:

    • Complete clinical remission was achieved in both patients.
    • The first patient responded to levamisole but succumbed to sepsis; autopsy revealed no lymphoma.
    • The second patient achieved complete remission with epipodophyllotoxin VP16-213 and remains disease-free.

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    Implications:

    • Complete remission is achievable even after lymphomatous transformation.
    • Levamisole offers a less immunosuppressive treatment option for immunocompromised patients.
    • Epipodophyllotoxin VP16-213 demonstrates efficacy in treating advanced lymphoma cases.