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Autoimmune lymphocytic thyroiditis in dogs

S J Gosselin, C C Capen, S L Martin

    Veterinary Immunology and Immunopathology
    |January 1, 1982
    PubMed
    Summary
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    In pet dogs, lymphocytic thyroiditis is a common cause of hypothyroidism, resembling human Hashimoto

    Area of Science:

    • Veterinary Medicine
    • Immunology
    • Endocrinology

    Background:

    • Hypothyroidism is a common endocrine disorder in dogs.
    • Lymphocytic thyroiditis and idiopathic follicular atrophy are primary thyroid diseases linked to hypothyroidism in dogs.
    • Canine lymphocytic thyroiditis shares similarities with human Hashimoto's thyroiditis and avian lymphocytic thyroiditis.

    Purpose of the Study:

    • To investigate the immune basis of lymphocytic thyroiditis in pet dogs.
    • To explore the potential autoimmune mechanisms underlying canine hypothyroidism.
    • To compare canine thyroiditis with naturally occurring autoimmune thyroiditis models.

    Main Methods:

    • Morphological examination of thyroid lesions.
    • Detection of circulating thyroglobulin autoantibodies.

    Related Experiment Videos

  • Induction of thyroid lesions via local thyroidal graft-versus-host reaction in experimental dogs.

    • Main Results:

    • Lymphocytic thyroiditis and idiopathic follicular atrophy are the most frequent thyroid lesions associated with clinical hypothyroidism in dogs.
    • The presence of thyroglobulin autoantibodies suggests an immune-mediated process in canine lymphocytic thyroiditis.
    • Experimental induction of thyroid lesions mimicked naturally occurring autoimmune thyroiditis, indicating an immune basis.

    Conclusions:

    • Canine lymphocytic thyroiditis is an immune-mediated disease.
    • Autoimmune thyroiditis in dogs can develop secondary to other immune responses.
    • Understanding the immune mechanisms is crucial for managing canine hypothyroidism.